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Major Depression (Depressive) Disorder

Updated: Mar 12, 2021

Five or more of the following A Criteria (at least one includes A1 or A2)

A1- Depressed mood—indicated by subjective report or observation by others (in children and adolescents, can be irritable mood)


A2- Loss of interest or pleasure in almost all activities—indicated by subjective report or observation by others.


A3 - Significant (more than 5 percent in a month) unintentional weight loss/gain or decrease/increase in appetite (in children, failure to make expected weight gains).


A4 -Sleep disturbance (insomnia or hypersomnia).



A5- Psychomotor changes (agitation or retardation) severe enough to be observable by others.


A6 -Tiredness, fatigue, or low energy, or decreased efficiency with which routine tasks are completed.


A7 - A sense of worthlessness or excessive, inappropriate, or delusional guilt (not merely self-reproach or guilt about being sick)


A8 - Impaired ability to think, concentrate, or make decisions—indicated by subjective report or observation by others.


A9 - Recurrent thoughts of death (not just fear of dying), suicidal ideation, or suicide attempts.


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